Location:Home / Journals / Article Detail

International Journal of Food Science and Agriculture


PDF Download

A Review on Medicinal Plant Piper cubeba L. and Its Pharmaceutical Properties

Pradeep Kumar

Department of Zoology, S. G. N. Government P.G. College, Muhammadabad, Gohna, Mau-276403 (U.P.), India.

*Corresponding author: Pradeep Kumar

Date: March 19,2021 Hits: 319


Plants are regarded as the richest research for many potential drugs. Medicinal plants have been used for the treatment of various diseases since ancient time. The bioactive compounds like different phytochemicals are extracted from various parts of the medicinal plants, as they serve as traditional herbal drugs. These drugs are well recognized in modern medication system due to natural products, much safer, effective in curing various diseases and it have less side effects. The secondary metabolite like tannine, saponin, flavonoids, alkaloids and phenolic compounds are widely used in pharmaceuticals. Therefore, some plants are usage as medicine for curing different diseases. Piper cubeba (Kabab Chini) is tropical medicinal plants which are common in Indonesia and different parts of the world. It has been reported that Piper cubeba is potential medicinal plant which has various phytochemicals and its uses in antimicrobial, anti-inflammatory, antibacterial, antioxidant, anti-cancerous, hepatoprotective, nephroprotective and antileishmanial activity. Thus, the aim of this review of literatures is to describe the phytochemicals and pharmaceutical attributes of Piper cubeba, which possess a broad range in biological activities.


[1] Dyer Lee, A., Aparna, D. N., and Palmar. (2004). Piper: A model genus for studies phytochemistry ecology and evolution. Kluwer Acadeamic plenum Publication New York, p. 2.

[2] Chirstopher, W. (2006). Medicinal plant of Asia and Pacific CRC. Tylor and Francis Boca raton Publisher London, p. 23.

[3] Varsha, H. and Sonali, S. (2014). Studies on qualitative phytochemical analysis of selected species of Piper. Int. J. Life Sci., 2: 156-8.

[4] Anonymous. (2005). The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products, First Supplement Series, Vol. 8, [Ph-Re]. (NISCAIR, Council of Scientific and Industrial Research, New Delhi), pp. 94-96.

[5] Parmar, V. S., Jain, S. C., Bisht, K. S., Jain, R., Taneja, P., Jha, A., Tyagi, O. D., Prasad, A. K., Wengel, J., and Olsen, C. E. (1997). Phytochemistry of the genus Piper. Phytochemistry, 46: 597-673.

[6] Robert, B. (2002). Medicinal plants. Asiatic publishing houses, New Delhi, 4: 243.

[7] Chatterjee, A. and Pakrashi, S. C. (1991). The Treatise on Indian Medicinal Plants, Vol. 1. (NISCAIR, Council of Scientific and Industrial Research, New Delhi), pp. 28-29.

[8] Prajapati, D. N., Purohit, S. S., Sharma, A. K., and Kumar, T. (2003). A Handbook of Medicinal Plants. Agrobois, India, p. 544.

[9] Khare, C. P. (2004). Encyclopaedia of Indian Medicinal Plants. Springer Berlin, Heideberg, New York, p. 366.

[10] Susan, P. and Margret, O. (2004). Botanica Konemann. Publication Random house Australia Pty Ltd., p. 683.

[11] Ahmad, W., Hasan, A., Abdullah, A., and Tarannum, T. (2012). An appraisal of Medicinal properties of Kabab Chini (Piper cubeba). Unimed Kulliyal, V(2): 13-18.

[12] Ahmad, Q. Z., Rahman, A. Z., and Tajuddin. (2017). Ethnobotant and therapeutic potential of Kabab Chini (Piper cubeba). World Journal of Pharmacy and Pharmaceutical Sciences, 6(8): 2418-2436.

[13] Barrett, B. (1994). Medicinal plants. Nicaragua’s Atlantic Coast Economic Botany, 481: 8-20.

[14] Joly, L. G. (1981). Feeding and trapping fish with Piper auritum. Econ. Bot., 35: 383-390.

[15] Chopra, R. N., Chopra, I. C., Handa, K. L., and Kapoor, L. D. (1958). Indigenous Drugs of India. U.N. Dhur and Sons Private Limited 15, Bankim Chattergee Street Calcutta, 12: 224-226.

[16] Eisai, P. T. (1995). Medicinal Herb Index in Indonesia. 2nd edition. Dian Rakyat. Jakarta, p. 21.

[17] Barch, D., Barve, N., Gupta, K., Chandra, S., Jain, N., Tiwari, S., Leon-Sicairos, N., Canizalez-Roman, A., Rodrigues dos Santos, A., and Hassan, S. S. (2013). Exoproteone and secretome derived broad spectrum novel drug and vaccine candidates in Vibrio cholera targeted by Piper betel derived compounds. PLOS One, 8: e52773.

[18] Jensen, S., Hansen, J., and Boll, P. M. (1993). Lignans and neolignans from Piperaceae (Review). Phytochemistry, 33: 523-530.

[19] Wu, Q., Wang, S., Tu, G., Feng, Y., and Yang, J. (1997). Alkaloids from Piper puberullum. Phytochemistry, 44: 727-730. 

[20] Rastogi, Ram P. and Mehrotra, B. N. (2002). Compendium of Indian medicinal plants, Vol. Published by National Institute of Science Communication, New Delhi, 1985-Vol. 4: 1989-569.

[21] Bos, R., Woerdenbag, H. J., Kayser, O., Quax, W. J., Ruslan, K., and Elfami. (2007). Essential oil constituents of Piper cubeba L. fils. from Indonesia. J. Essent. Oil Res., 19: 14-17.

[22] Alam, M. A., Ahmed, S., Husain, S., Bano, H., and Ahmed, Z. (2013). Kabab Chini (Piper cubeba) and Its Healing Corollary in Unani Medicine: An overview. American Journal of Pharmacy and Gealth Research, 1(6): 1-9.

[23] Parmar, V. S., et al. (1997). Phytochemistry of the genus Piper. Phytochemistry, 46: 597-673.

[24] Usia, T., Watabe, T., Kadota, S., and Tezuka, Y. (2005). Potent cyp3A4 inhibitory constituents of Piper cubeba. Journal of Natural Products, 68: 64-68.

[25] Prabhu, B. R. and Mulchandani. (1985). Lignans from Piper cubeba. Phytochemistry, 24(2): 329-331.

[26] Badheka, L. P., Prabhu, B. R., and Mulchandani, N. B. (1986). Dibenzylbutyrolactone lignin from Piper cubeba. Phytochemistry, 25: 487-489.

[27] Badheka, L. P., Prabhu, B. R., and Mulchandani, N. B. (1987). Lignans from Piper cubeba. Phytochemistry, 26: 2033-2036.

[28] Koul, J. L., Koul, S. K., Taneja, S. C., and Dhar, K. L. (1996). Oxygenated cyclohexanes from Piper cubeba. Phytochemistry, 41: 1097-1099. 

[29] Bharathi, R. P. and Newand, B. M. (1985). Lignans from Piper cubeba. Phytochemistry, 24(2): 329-331.

[30] Pachpute, A. P. and Tushar, A. (2012). Deshmukh. International Journal of Pharma World Research, 3(4): 1-12.

[31] Magalhaes, L. G., de Souza, J. M., Wakabayashi, K. A. L. (2012). In vitro efficacy of the essential oil of Piper cubeba L. (Pi-peraceae) against Schistosoma mansoni. Parasitol. Res., 110: 1747-1754.

[32] Mothana, R., Alsaid, M., Khaled, J. M., Alharbi, N. S., Alatar, A., Raish, M., Al-Yahya, M., Rafatullah, S., Parvez, M. K., Ahamad, S. R. (2016). Assessment of antinociceptive, antipyretic and antimicrobial activity of Piper cubeba L. essential oil in animal models. Pak. J. Pharm. Sci., 29: 671-677.

[33] Chaubey, M. K. (2011). Insecticidal properties of Zingiber officinal and Piper cubeba essential oils against Tribolium castaneum Herbst (Coleoptera: Tenebrionidae). J. Biol. Act. Prod. Nat., 1: 306-313.

[34] Muraleedharan, G. N., Basil, A., and Burke. (1990). Antimicrobial Piper Metabolite and Related Compounds. J. Agric. Food Chem, 38: 1093-1096.

[35] Tamadher, M. K. and Tememy, Al. (2013). Antibacterial activity of Piper cubeba Linn. Fruit extracts against selected bacterial pathogens in Basrah city. Bas. J. Vet. Res., 12(1): 142-151.

[36] Choi, E. M., and Hwang, J. K. (2003). Investigation of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalia angulata and Rosa hybrid. Journal of Ethnopharmacology, 89: 171-175.

[37] Van den Worm, E., Beukelman, C. I., Van de Bery., Albert, J. J., Kroes, B. H., Labadie, R. P., and Van Dijk, H. (2001). Effects of merhoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neu-trophils. European Journal of Pharmacology, 433: 225-230.

[38] Tapiero, H., Ba, G. N., Couvreur, P., and Tew, K. (2002). Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomedicine and Pharmacotherspy, 56: 215-222.

[39] Muchandi, A., and Dhawale, S. (2018). A review on Piper cubeba L: A potential medicinal plant. Current Research Journal of Pharmaceutical and Allied Sciences, 2(2): 1-4.

[40] Ramzi, M., Mansour, A., Jamal, M. K., Naiyf, S. A. Abdulrahman, A., Mohammad, R., and Syed, R. A. (2016). Assessment of antinociceptive antipyretic and antimicrobial activity of Piper cubeba L., essential oil in animal models. Pak. J. Pharm. Sci., 29(2): 671-677.

[41] Desouza, V. A., Da silva, R., Pereira, A. C., Roya, V. D., Saraiva, J., and Montanheiro, M., et al. (2005). Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosomacruzi. Bioorganic & Medicinal Chemistry Letters, 15: 303-307.

[42] Bastos, J. K., Carvalho, J. C. T., de Souza, G. H. B., Pedrazzi, A. H. P., and Sarti, S. J. (2001). Antiinflammatory activity of cubebine, a lignin from the leaves of Zanthoxyllum naranjillo Griseb. Journal of Ethanopharmacology, 75: 279-282.

[43] Al-Tememy, T. M. K. (2013). Antibacterial activity of Piper cubeba Linn. Fruit extracts against selected bacterial pathogens. Bas. J. Vet. Res., 12(1): 142-151.

[44] Khan, M., Siddiqui, M. (2007). Antimicrobial activity of Piper fruits. Natural Product Radiance, 6(2): 111-113.

[45] Muchandi, A. A., Jadhav, A. S., Patil, S. B., Patil, S.A., and Jadhav, N. B. (2018). Antioxidant and in vitro Antidiabetic activity of methanol extract of Piper cubeba L. International Research Journal of Pharmacy and Medical Sciences, 1(3): 1-4.

[46] Nahak, G., Sahu, R. K. (2011). Phytochemical Evaluation and Antioxidant activity of Piper cubeba and Piper nigrum. Journal of Applied Pharmaceutical Science, 01(08): 153-157.

[47] Aboul-Enein, H.Y., et al. (2010). Radical Scavenging Ability of Some Compounds Isolated from Piper cubeba towards free Radicals. Luminescence, 26(3): 202-207.

[48] Choi, E. M. and Hwang, J. K. (2005). Effect of some medicinal plants on plasma antioxidant system and lipid levels in rats. Phytotherapy Research, 19(5): 382-386.

[49] Gaytri, N., Sahu, R. K. (2011). Phytochemical Evalution and Antioxidant activity of Piper cubeba and Piper nigrum. J. Appl. Pharm. Sci., 1(8): 153-157.

[50] Muchandi, A. A., Dhawale, S. C. (2017). Pharmacognostic evaluation and free radical scavenging activity of ethanolic extract of Piper cubeba fruits. Asian J. Phytomed Clin. Rese., 5(2): 42-52.

[51] Yam, J., Schaab, A., Kreuter, M., and Drewe, J. (2008). Piper cubeba demonstrates anti-estrogenic and anti-inflammatory properties. Planta Medica, 74(2): 142-146. 

[52] Yam, J., Kreuter, M., and Drewe, J. (2008). Piper cubeba targets multiple aspects of the androgen signaling pathway, a potential phytotherapy against prostate cancer growth. Planta Medica, 74(1): 33-38. 

[53] Bezerra, D., Castro F., Alves, A., Pessoa, C., Moraes, M., Silveira, E., Lima, M., Elmiro, F., and Costa-Lotufo, L. (2006). In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal of Medical and Biological Research, 39: 801-807.

[54] Jyothi, D., Vanathi, P., Gowri, P. M., Rao, V. R. S., Rao, J. M., and Dreedhar, A. (2009). Diferuloymethane augments the cyti-toxic effects of piplartine isolated from Piper chaba. Toxicology In vitro, 23:1085-1091.

[55] Bokesch, H. R., Gardella, R. S., Rabe, D. C., Bottaro, D. P., Limehan, W. M., McMahon, J. B., and Makee, T. C. (2011). A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems Piper sarmentosum. Chemical and Phar-maceutical Bulletin, 59: 1178-1179.  

[56] Ferreira, A. K., de-Sa-Junior, P. L.., Pasqualoto, K. F. M., de Azevedo, R. A., Camara, D. A. D., Costa, A. S., Figueiredo, C. R., Matsuo, A. L., Massaoka, M. H., and Auada, A. V. V. (2014). Cytotoxic effect of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative tress while altering the cytoskeleton network. Biochimie, 99: 195-207.

[57] Kuete, Y., Sandjo, L. P., Wiench, B., and Efferth, T. (2013). Cytotoxicity and modes of action of four Cameroonian dietary species ethno-medically used to treat cancer: Echinops giganteus, Xylopia aethiopica, Imperata cylindrical and Piper capense. Journal of Ethnopharmacology, 149: 245-253. 

[58] Iwamoto, L. H., Vendramini-Costa, D. B., Monteiro, P. A., Ruiz, Ana Lucia Tasca Gois, Sousa Ilza Maria de Oliveira, Foglia, M. A., de Carvalho, J. E., and Rodrigues, R. A. F. (2015). Anticancerous and anti-inflammatory activities of a standardized dichloromethane extract from Piper umbellatum L. leaves. Evide Based Complement and Alternat Med., 2015: 948737. 

[59] Potchanapond, G., Mananya, M., and Yaowapa, S. (2015). Cytotoxic Activity of Piper cubeba extract in breast cancer cell lines. Nutrients, 7: 2707-2718.

[60] Bezerra, D. P., Pessoa, C., Moraes, M. O. D., Silveira, E. R., Lima, M. A. S., Martins Elmiro, F. J., and Costa-Lotufo, L. V. (2005). Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift fur Naturforschung, Section C. 60: 539-543.

[61] Chen, L. H., Fang, J., Li, H., Demark-Wahnefried, W., and Lin, X. (2007). Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway. Mol Cancer Ther., 6: 2581-2590.

[62] Fini, L., Hotchkiss, E., Fogliano, V., Graziani, G., Romano, M., De Vol, E. B., Qin, H., Selgrad, M., Boland, C. R., and Ric-ciardiello, L. (2008). Chemopreventive properties of pinoresinol-rich olive oil involve a selective action of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis, 29: 139-146.

[63] K. B. Harikumar, K. B., Sung, B., Tharakan, S. T., Pandey, M. K., Joy, B., Guha, S., Krishnan, S., and Aggarwal, B. B. (2010). Sesamin manifests Chemopreventive effects through the suppression of NF-kB-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol. Cancer Res., 8(5): 751-761. 

[64] Yoo, J. H., Lee, H. J., Kang, K., Jho, E. H., Kim, C. Y., Baturen, D., Tunsag, J., Nho, C. W. (2010). Lignans inhibit cell growth via regulation of Wnt/β-catenin signaling. Food and Chem. Toxicol, 48: 2247-2252. 

[65] Rajalekshmi, D. S., Kabeer, F. A., Madhusoodhanan, A. R., Bahulayan, A. K., Prathapan, R., Prakasan, N., Varughese, S., and Nair, M. S. (2016). Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives. Bioorganic and Medicinal Chemistry Letter, 26(7): 1767-1771. 

[66] Kumar, N., Misra, P., Dube, A., Bhattacharya, S., Dikshit, M., and Ranade, S. (2010). Piper betle Linn. A maligned Pan-Asiatic plant with an array of pharmacological activities and prospects for drug discovery. Current Science, 99: 922-933.

[67] Pachpute, A. P., et al. (2013). Antioxidant and Hepatoprotective Activity of an Ethano Extract of Piper cubeba fruits. Int. J. Res. Dev. Pharm. L. Sci., 2(2): 321-329.

[68] Thabrew, M., Jouce, P., and Rajatissa, W. (1987). Comparative study of efficacy of Paetta indica and Osbeckia octandra in the treatment of liver dysfunction. Planta Media, 53: 239-241.

[69] Kavitha, M., et al. (2011). Hepatoprotective Activity of a Poly Herbal Extract in Carbon Tetra Chloride Intoxicated Hepatotoxicity In Male Albino Rats. International Journal of Pharma and Bio Sciences, 2(3): 307-312.

[70] Bhattacharjee, S. K. (2004). Hand Book of Medicinal Plants. 4thedition. Published by Pointer Publishers, p. 269.

[71] Qazi, Z. A., Jahan, N., Ahmad, G., and Tajuddin. (2012). Nephroprotective effect of Kabab Chini (Piper cubeba) in Gentamycin induced nephrotoxicity. Saudi J Kidney Dis Transplan, 23(4): 773-781.

[72] Ahmad, Q. Z. (2008). Evaluation of Nephroprotective effect of Kabab Chini (Piper cubeba) in chemically induced nephrotoxicity. Deptt. of Ilmul Advia, NIUM, Bangalore, MD Thesis, pp. 53-54. 

[73] Hardik, S., Bodiwala, G. Singh, C., Sankar, D., Shyam, S. S., Kamlesh, K. B., Inder Pal Singh, et al. (2007). Antileshmanial amides and lignans from Piper cubeba and Piper retrofractum. Journal of Natural Medicine, 61: 481-482.

Full-Text HTML

A Review on Medicinal Plant Piper cubeba L. and Its Pharmaceutical Properties

How to cite this paper: Pradeep Kumar. (2021) A Review on Medicinal Plant Piper cubeba L. and Its Pharmaceutical Properties. International Journal of Food Science and Agriculture5(1), 174-179.

DOI: http://dx.doi.org/10.26855/ijfsa.2021.03.022