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The Concept of a Compound Autopsy Experimental Laboratory for SARS-CoV-2 Aerosolization Studies

Izak B. Dimenstein

Loyola University Chicago Medical Center (Ret.), USA.

*Corresponding author: Izak B. Dimenstein

Date: April 1,2021 Hits: 965


This viewpoint material suggests the concept of a compound autopsy experimental laboratory for SARS-CoV-2 aerosolization studies. The autopsy room can provide at least three experimental models: wide open mucosa during the autopsy procedure, an experimental platform of sealed at the larynx level of the body’s upper respiratory tract, and a frozen section cryostat chamber, as an additional experimental site for an emulation the aerosolization process. The autopsy room can be merged with a virology laboratory. The goal of the compound autopsy experimental laboratory could be to study the conditions for SARS-CoV-2 aerosolization. A positive result could lead to a variety of additional studies on SARS-CoV-2, as such the viability of an aerosolized virus. The epidemiological implications of these studies are difficult to over-estimate. The method of such study would provide reliable reproduceable experimental data for use now and in a variety of applications in the future.


[1] G. Correia, L. Rodrigues, M. Gameiro da Silva, Gonçalvesa, T. (2020). Airborne route and bad use of ventilation systems as non-negligible factors in SARS-CoV-2 transmission. Medical Hypotheses, Volume 141, December 27, 2020, 109781. https://doi.org/10.1016/j.mehy.2020.10978.

[2] Morawska, L., Milton, D. K. (2020). It is time to address airborne transmission of COVID-19. Clin Infect Dis., 2020 Jul 6 Available from: https://doi.org/10.1093/cid/ciaa9392. 

[3] Asadi, S., Bouvier, N., Wexler, A. S., Ristenpart, W. D. (2020). The coronavirus pandemic and aerosols: Does COVID-19 transmit via expiratory particles? Aerosol Science and Technology, Volume 54, 2020, Issue 6, Pages 635-638. Received 26 Mar 2020, Accepted 26 Mar 2020, Published online: 03 Apr 2020 https://doi.org/10.1080/02786826.2020.1749229.

[4] CDC Interim Guidance for Collection and Submission of Postmortem Specimens from Deceased Persons with Known or Sus-pected COVID-19. https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-postmortem-specimens.html (accessed December 27, 2020).

[5] World Health Organization. (‎2020)‎. Infection prevention and control for the safe management of a dead body in the context of COVID-19: interim guidance, 24 March 2020. World Health Organization. https://apps.who.int/iris/handle/10665/331538. Li-cense: CC BY-NC-SA 3.0 IGO (accessed December 27, 2020).

[6] OSHA COVID-19—Control and Prevention/Postmortem Care Workers and Employers; https://www.osha.gov/SLTC/covid-19/ postmortem-care.html (accessed December 27, 2020).

[7] Kim, S. W., Ramakrishnan, M. A., Raynor, P. C., Goyal, S. M. (2007). Effects of humidity and other factors on the generation and sampling of a coronavirus aerosol. Aerobiologia, 24 Jul 2007, 23(4): 239-248. DOI: 10.1007/s10453-007-9068-9 PMID: 32214623 PMCID: PMC7087841.

[8] Hogan, C. J. Jr., E. M. Kettleson, M.‐H. Lee, B. Ramaswami, L. T. Angenent, P. Biswas. (2005). Sampling methodologies and dosage assessment techniques for submicrometre and ultrafine virus aerosol particles. Journal of Applied Microbiology, 13 September 2005. https://doi.org/10.1111/j.1365-2672.2005.02720.x.

[9] Dombrovsky, L. A., Fedorets, A. A., Yu, V., Levashov, Kryukov, A. P., Bormashenko, E., and Nosonovsky, M. (2020). Mod-eling Evaporation of Water Droplets as Applied to Survival of Airborne. Viruses Atmosphere, 2020, 11(9), 965. https://doi.org/10.3390/atmos11090965.

[10] Stadnytskyi, V., Bax, C. E., Bax, A., Anfinrud, P. (2020). The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proc. Natl. Acad. Sci. U. S. A., 117, 11875-11877. https://doi.org/10.1073/pnas. 2006874117.

[11] Vermaa, S., Dhanakb, M., Frankenfieldc, J. (2020). Visualizing the effectiveness of face masks in obstructing respiratory jets. Physics of Fluids., 32, 061708 (2020). https://doi.org/10.1063/5.0016018.

[12] Lindsley, W. G., Noti, J. D., Blachere, F. M., Szalajda, J. V., Beezhold, D. H. (2014). Efficacy of face shields against cough aerosol droplets from a cough simulator. J. Occup. Environ. Hyg., 11, 509-518 (2014).

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The Concept of a Compound Autopsy Experimental Laboratory for SARS-CoV-2 Aerosolization Studies

How to cite this paper: Izak B. Dimenstein. (2021) The Concept of a Compound Autopsy Experimental Laboratory for SARS-CoV-2 Aerosolization StudiesInternational Journal of Clinical and Experimental Medicine Research5(2), 161-165.

DOI: http://dx.doi.org/10.26855/ijcemr.2021.04.010