References

[1] Chen Jing, Lv Wenliang. (2021). Research progress in prevention and treatment of functional constipation with traditional Chinese medicine [J]. Journal of Liaoning University of traditional Chinese medicine, 2021, 23(06): 134-140.

[2] Li Zhen, Zhong Shibiao, Nong Jianzheng. (2021). Progress in the treatment of chronic functional constipation with traditional Chinese medicine [J]. China prescription drugs, 2021, 19(06): 17-19.

[3] Wang Fang, Zhang Yanli, Yao Shukun, Ma Junyu. (2014). Symptom characteristics and intestinal microecology analysis of patients with severe functional constipation [J]. Journal of difficult diseases, 2014, 13(07): 707-709+713.

[4] Xu Nana, Fan Wenting, Bi Ruru, Qin Tingting, Ma Ping, Gu Bing. (2018). Research progress in intestinal flora analysis and intestinal flora regulation in patients with functional constipation [J]. Journal of clinical laboratory, 2018, 36(01): 34-36.

[5] Zhang Runtao, Liu Cong, Zhang Yue, Li Jia, Ni Yan, Kang Yong. (2021). Research Progress on the correlation between functional constipation and intestinal flora [J]. Chinese medical science, 2021, 11(22): 31-34.

[6] Chinese guidelines for the diagnosis and treatment of chronic constipation (2013, Wuhan) [J]. Gastroenterology, 2013, 18(10): 605-612.

[7] Shahid Shabana, Ramzan Zeeshan, et al. (2012). Chronic idiopathic constitution: more than a simple colonial transit disorder [J]. Journal of clinical gastroenterology. Volume 46, issue 2, 2012. PP. 150-4.

[8] Tomasello, G., Bellavia, M., Palumbo, V. D., et al. (2011). From gut microfloraImbalance to mycobacteria infection: is there a relationship with Chro-NIC internal inflammatory diseases [J]. Ann international chir, 2011, 82(5): 361-368.

[9] Backed, F., Fraser, C. M., Ringel, Y., et al. (2012). Defining a health human gut microbiome: current concepts, future directions, and clinical application-Ions [J]. Cell host microbe, 2012, 12: 611-622.

[10] Arnolds, K. L. (2016). Striking a balance with help from our little friends how the gut microbiota contributions to immune homestasis [J]. Yale J Biol Med, 2016, 89(3): 389-395.

[11] Bi Hongling, Zhang Guilan. (2003). He fan Investigation of intestinal flora in patients with constipation [J]. Clinical military miscellaneous Zhi, 2003, 31(3): 82-84.

[12] Khalif, I. L., Quigley, E. M., Konovitch, E. A., et al. (2005). Alternatives in the colonial flora and internal predictability and evidence of im ⁃ muneactivation in synchronous constipation [J]. Dig liver DIS, 2005, 37(11): 838-849.

[13] Miao Yongxin, Yu shaolei, Yang Ailong, et al. (2014). Study on the changes of intestinal flora in patients with constipation [J]. Chinese Journal of anorectal diseases, 2014, 34(10): 53-54.

[14] De Meij TG, de Groot EF, Eck A, et al. (2016). Characterization of MI ⁃ crobiota in children with modern functional constitution [J]. PLoS One, 2016, 11(10): e0164731. Doi: 10.1371/journal Pone one hundred and sixty-four thousand seven hundred and thirty-one.

[15] Zhang Xu, Pan Renzhi, Zhang Xiaoling, et al. (2004). Investigation on the ecological distribution of intestinal flora in non constipated and constipated elderly in Nanjing [J]. Journal of Nanjing University of traditional Chinese medicine, 2004, 20(5): 287-288.

[16] Wang Fang, Zhang Yanli, Yao Shukun, et al. (2014). Symptom characteristics and intestinal microecology of patients with severe functional constipation [J]. Journal of difficult diseases, 2014, 13(7): 707-709.

[17] Barbara g, standhellini V, Brandi g, et al. (2005). Interactions between commercial bacteria and gut sensorimotor function in health and disease [J]. Am J gastroenterol, 2005, 100(11): 2560-2568.

[18] Liu Haining, Chen yuzhuo, Wu Hao, et al. (2015). Research progress of intestinal flora and functional constipation [J]. Journal of Fudan University (Medical Edition), 2015, 42(4): 564-568.

[19] Wang Junli, Nie Guoxing. (2011). Research progress of xylooligosaccharides and intestinal microecology [J]. World Chinese Journal of digestion, 2011, 19(7): 710-717.

[20] Hu Shuangli, Liu Yuntao. (2018). Probiotics combined with procarbil succinate in the treatment of chronic functional constipation [J]. Chinese Journal of Integrated Chinese and Western medicine surgery, 2018, 24(05): 625-627.

[21] Peng Rujie, Zeng Qingxin. (2018). Clinical study of probiotics combined with lactulose in the treatment of functional constipation in the elderly [J]. Modern medicine and health, 2018, 34(04): 576-578.

[22] Qian Min, Liu Fengbing, Li Zhen, Yuan Jin, Wu Jieyuan, Meng Cuicui, Ding Li. (2021). Clinical observation on the treatment of senile chronic functional constipation with lactulose and two probiotics [J]. Shanghai pharmaceutical, 2021, 42(22): 35-37+44.

[23] Jiang Sasha, Liu Yuedong, Han Bao. (2020). Observation on the clinical efficacy of probiotic fiber powder in the treatment of functional constipation [J]. People’s military medicine, 2020, 63(07): 697-700.

[24] Yang Yinzhuo, Zhang Yan, Chen Li. (2021). Research progress of prebiotics/probiotics in the treatment of functional constipation in children [J]. Chinese medical science, 2021, 11(18): 40-43+69.

[25] Zhong Jingye, Cheng Shuangping, Yao Xin, Yang Dehui, Huang Qi, Zhao Tao, Liang guojun, Xu tingyuan. (2018). Clinical observation on mosapride citrate combined with lactulose in the treatment of refractory functional constipation in the elderly [J]. Clinical misdiagnosis and mistreatment, 2018, 31(11): 30-33.

[26] Lei Yanwei, Cheng ling, Zhu yanbo. (2012). Effect of lactulose on children with functional constipation [J]. Journal of clinical rational drug use, 2012, 5(12): 50-51.

[27] Jin Qingchong, Chen Yue, Song Jiao. (2018). Application of heshengyuan preparation in the treatment of functional constipation [J]. Practical drugs and clinic, 2018, 21(11): 1279-1282.

[28] Huang Linsheng, Zhu Qi, Gao Renyuan, Yan Xuebing, Li Hao, Qu Xiao, Kong Cheng, Shen Tongyi, Qin Huanlong. (2018). Effect of synbiotic on chronic functional constipation and its effect on intestinal flora structure [J]. China National Academy of Sciences, 2018, 21(08): 908-913.

[29] Li Shijun, Wu Jianguo, Peng Zhiyang, Xiao Zhe, Wang Xufeng, Tong Qiang. (2019). Research progress of fecal bacteria transplantation in the treatment of chronic functional constipation [J]. China new clinical medicine, 2019, 12(01): 100-103.

[30] Liu Qiaoyun, Zhang Song, Cao Haichao, Li Tingyu, Ma Yubo, Zhao Xin, Jiang Mingzuo, Liu Jian, Hui Na, Wang Meixia, Nie Yan, Wu Kaichun, Nie Yongzhan. (2017). Effect of fecal bacteria transplantation on clinical efficacy and quality of life in patients with intractable functional constipation [J]. Chinese Journal of digestive diseases and imaging (Electronic Edition), 2017, 7(01): 4-8.

[31] Tian Yan, Zhou Yan, Zhou Jinggang, Huang Sisi, Li Xiao’an. (2018). Research progress of fecal bacteria transplantation in the treatment of functional constipation [J]. Modern clinical medicine, 2018, 44(02): 158-160.