Article http://dx.doi.org/10.26855/ijcemr.2024.04.004

Assessing the Prognostic Value of Serum PLGF, sFlt-1, and sFlt-1/PLGF Ratios in Predicting Adverse Pregnancy Outcomes in Preeclampsia: A Comprehensive Analysis


Min Liu1, Weicong Liang3, Yitong Lu2, Yanqin Liu2, Meng Li2, Xinwen Zhang2,*

1Second Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, China.

2Department of Women's Health, Xi'an People's Hospital, Xi'an, Shaanxi, China.

3Xi'an Medical University, Xi'an, Shaanxi, China.

*Corresponding author: Xinwen Zhang

Published: May 21,2024


Objective: This study investigates the correlation between serum levels of placental growth factor (PLGF), soluble FMS-like tyrosine kinase-1 (sFlt-1), and the sFlt-1/PLGF ratio, and adverse pregnancy outcomes in preeclampsia (PE) patients. Methods: We analyzed data from 1,383 pregnant women diagnosed with preeclampsia at Xi'an People's Hospital (No. 4 Hospital of Xi'an) from July 2022 to June 2023. The participants were categorized into a PE group of 95 individuals, further divided into 53 with mild preeclampsia (mPE) and 42 with severe preeclampsia (sPE), and a control group of 1,288 individuals. The PE group was also subdivided based on pregnancy outcomes into a poor outcome subgroup (367 cases) and a normal delivery subgroup (1,015 cases). Serum PLGF, sFlt-1, and sFlt-1/PLGF levels were measured and analyzed in relation to pregnancy outcomes. Results: The PE group exhibited significantly lower PLGF levels and higher sFlt-1 and sFlt-1/PLGF levels compared to the control group. Within the PE group, the sPE subgroup had significantly lower PLGF and higher sFlt-1/PLGF levels than the mPE subgroup. Patients with adverse outcomes showed significantly higher sFlt-1 and sFlt-1/PLGF levels compared to those with normal delivery outcomes. Spearman correlation analysis indicated a negative correlation between PLGF levels and adverse pregnancy outcomes (ρ = -0.057, P < 0.05), and a positive correlation of sFlt-1 and sFlt-1/PLGF levels with adverse outcomes (ρ = 0.075 and 0.082, respectively; both P < 0.01). Conclusion: Lower serum PLGF and higher sFlt-1 and sFlt-1/PLGF levels are significantly associated with PE and adverse pregnancy outcomes, underscoring their potential as biomarkers for predicting pregnancy complications in PE patients.


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How to cite this paper

Assessing the Prognostic Value of Serum PLGF, sFlt-1, and sFlt-1/PLGF Ratios in Predicting Adverse Pregnancy Outcomes in Preeclampsia: A Comprehensive Analysis

How to cite this paper: Min Liu, Weicong Liang, Yitong Lu, Yanqin Liu, Meng Li, Xinwen Zhang. (2024) Assessing the Prognostic Value of Serum PLGF, sFlt-1, and sFlt-1/PLGF Ratios in Predicting Adverse Pregnancy Outcomes in Preeclampsia: A Comprehensive AnalysisInternational Journal of Clinical and Experimental Medicine Research8(2), 216-221.

DOI: http://dx.doi.org/10.26855/ijcemr.2024.04.004