IJCEMR

Article http://dx.doi.org/10.26855/ijcemr.2024.04.017

Evaluation of the Efficacy and Side Effects of Montelukast Sodium Combined with Salmeterol in Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome

TOTAL VIEWS: 274

Yao Wan1,*, Tingting Zhang1, Anding Zhang2, Anshun Fan3

1Tongzi County Hospital of Traditional Chinese Medicine, Tongzi, Zunyi, Guizhou, China.

2People's Hospital of Tongzi County, Tongzi, Zunyi, Guizhou, China.

3People's Hospital of Fenggang County, Fenggang, Zunyi, Guizhou, China.

*Corresponding author: Yao Wan

Published: May 24,2024

Abstract

Objective: To evaluate the efficacy and adverse reactions of Montelukast sodium combined with salmeterol in asthma-chronic obstructive pulmonary disease overlap syndrome. Methods: A total of 290 patients with asthma-chronic obstructive pulmonary disease overlap syndrome admitted to our hospital from June 2022 to July 2023 were divided into a study group and control group by random number table method, with 145 cases in each group. The control group was given salmeterol treatment, while the study group was given Montelukast sodium combined with salmeterol treatment for 6 consecutive months. The therapeutic effect, lung function before and after treatment, and treatment safety were evaluated and compared between the two groups. Results: After treatment, the total effective rate of the study group was higher than that of the control group, the pulmonary function indexes such as FVC and PEF were higher than those of the control group, and the incidence of treatment-related adverse reactions was lower than that of the control group, with statistical significance (P < 0.05). Conclusion: Montelukast sodium combined with salmeterol has higher efficacy and safety in the treatment of patients with asthma-chronic obstructive pulmonary disease overlap syndrome, and can effectively improve the lung function of patients.

References

[1] Behrouz S, Emirhan N, Ali T, et al. Biomarkers in exhaled breath condensate as fingerprints of asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap: a critical review [J]. Biomarkers in Medicine, 2024.

[2] Shen H, Xu Y, Zhang Y, et al. Correlation Between Diaphragmatic Excursion and Exercise Tolerance Improvement Following Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease-Obstructive Sleep Apnea Overlap Syndrome [J]. International Journal of Chronic Obstructive Pulmonary Disease, 2024, 19.

[3] Alhajery A M. Correction: The Overlap Syndrome: A Combination of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea [J]. Cureus, 2024, 16(1).

[4] Alhajery A M. The Overlap Syndrome: A Combination of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea [J]. Cureus, 2024, 16(1).

[5] Zhu Z, Wu Y, Qu L, et al. Evaluation of nocturnal apnea and airflow limitation as indicators for cognitive dysfunction in patients with chronic obstructive pulmonary disease/obstructive sleep apnea hypopnea syndrome overlap syndrome [J]. Chronic Respira-tory Disease, 2024, 21.

[6] D B, M O, M J O, et al. Global Lung Initiative as diagnostic criteria in Asthma-COPD overlap syndrome. Prevalence and characterization of the syndrome in a real-life asthma cohort [J]. Journal of Investigational Allergology & Clinical Immunology, 2023.

[7] D. W S. Asthma Chronic Obstructive Pulmonary Disease Overlap: Defining, Naming, Diagnosing, and Treating Asthma-Chronic Obstructive Pulmonary Disease Overlap [J]. Physician Assistant Clinics, 2023, 8(4).

[8] Banjade P, Kandel K, Itani A, et al. The Interplay between Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, and Congestive Heart Failure: Time to Collectively Refer to Them as Triple Overlap Syndrome? [J]. Medicina, 2023, 59(8).

[9] Han XH, Han FF, Wang HQ. Effect of high-flow oxygen inhalation combined with tiotropium bromide powder in the treatment of chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome [J]. Journal of Clinical Medicine Re-search and Practice, 2019, 8(34):53-56.

[10] Yu YJ. Effects of traditional aerobic exercise on cognitive ability and quality of life in patients with chronic obstructive pulmonary disease and obstructive sleep apnea hypopnea syndrome overlap syndrome [C]//Chinese Society of Sports Science. Abstract col-lection of the 13th National Sports Science Conference—Wall Newspaper Exchange (Sports Medicine Branch), (1), 2023:3.

[11] Xu XT. Effect of Montelukast sodium combined with salmeterol ticasone inhalation powder on pulmonary function improvement in patients with asthma-chronic obstructive pulmonary disease overlapping syndrome [J]. Journal of Modern Medicine and Health Research, 2019, 7(03):66-69.

[12] Wang QQ, Qiao BJ. Effect of Montelukast sodium tablets combined with Salmeteroticasone inhalation powder in the treatment of asthma-Chronic obstructive pulmonary disease overlap syndrome and its effects on oxidative stress indexes and immune function [J]. Journal of Clinical Medicine Research and Practice, 2019, 8(03):39-41.

How to cite this paper

Evaluation of the Efficacy and Side Effects of Montelukast Sodium Combined with Salmeterol in Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome

How to cite this paper:  Yao Wan, Tingting Zhang, Anding Zhang, Anshun Fan. (2024) Evaluation of the Efficacy and Side Effects of Montelukast Sodium Combined with Salmeterol in Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome. International Journal of Clinical and Experimental Medicine Research8(2), 281-285.

DOI: http://dx.doi.org/10.26855/ijcemr.2024.04.017