IJCEMR

Article http://dx.doi.org/10.26855/ijcemr.2024.07.025

Analysis of Active Ingredients and Mechanisms of Action in Sleep Supplements: A Study Based on Market Conditions

TOTAL VIEWS: 534

Zhuotao Zeng1, Huan Zeng1, Junjiong Lu1,2, Yuxi Huang1, Xiaoyun Wen1, Li Ding1,*

1Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, China.

2Guangdong Second Normal University, Guangzhou 510303, Guangdong, China.

*Corresponding author: Li Ding

Published: August 19,2024

Abstract

In recent years, with increasing attention to sleep quality, the market has seen a surge in supplements claiming to improve sleep. However, consumers often lack scientific guidance when purchasing these products. This paper aims to systematically analyze the active ingredients and mechanisms of action in various sleep supplements to provide scientific references. Through literature review and experimental research, this study identifies several common ingredients such as melatonin, valerian root, and schisandra that have shown some effectiveness in improving sleep quality. Additionally, the paper explores the mechanisms of these ingredients, including their regulatory effects on the central nervous system, influence on neurotransmitters, and antioxidant functions. The results indicate that different ingredients have varying effects on sleep improvement, influenced by factors such as dosage, duration of use, and individual differences. Finally, the paper suggests that consumers should base their choice and use of sleep supplements on scientific evidence and their personal conditions to achieve the best results in improving sleep quality.

References

[1] 2024 Sleep Research Blue Book Report. 

[2] 2024 Chinese Residents' Sleep Health White Paper.

[3] Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. 2007 Dec;16(4):372-80. doi: 10.1111/j.1365-2869.2007.00613.x. PMID: 18036082.

[4] Rondanelli M, Opizzi A, Monteferrario F, Antoniello N, Manni R, Klersy C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011 Jan; 59(1):82-90. doi: 10.1111/j.1532-5415.2010.03232.x. PMID: 21226679.

[5] Rajaratnam SM, Middleton B, Stone BM, Arendt J, Dijk DJ. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans. J Physiol. 2004 Nov 15; 561(Pt 1):339-51. doi: 10.1113/jphysiol.2004.073742. Epub 2004 Sep 30. PMID: 15459246; PMCID: PMC1665336.

[6] Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, Okubo T, Kunugi H. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017 Apr; 29(2):72-79. doi: 10.1017/neu.2016.33. Epub 2016 Jul 11. PMID: 27396868.

[7] Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3; 11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.

[8] Jang, H.S., Jung, J.Y., Jang, I.S., Jang, K.H., Kim, S.H., Ha, J.H., Suk, K., Lee, M.G., 2012. L-theanine partially counteracts caffeine-induced sleep disturbances in rats. Pharmacol. Biochem. Behav. 101, 217-221. https://doi.org/10.1016/j.pbb.2012.01. 011.

[9] White DJ, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey AB. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2016 Jan 19; 8(1):53. doi: 10.3390/nu8010053. PMID: 26797633; PMCID: PMC4728665.

[10] Kim S, Jo K, Hong KB, Han SH, Suh HJ. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharm Biol. 2019 Dec; 57(1):65-73. doi: 10.1080/13880209.2018.1557698. PMID: 30707852; PMCID: PMC6366437.

[11] Zhang Ying, Wang Xin, Liu Yajuan, et al. L-Theanine Improves Sleep: Research Progress. Food Industry Science and Technol-ogy, 2021, 42(16): 361-366. DOI:10.13386/j.issn1002-0306.2020070289.

[12] Chandra Shekhar H, Joshua L, Thomas JV. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Hu-man Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study. Adv Ther. 2024 Jan; 41(1):246-261. doi: 10.1007/s12325-023-02708-6. Epub 2023 Oct 30. PMID: 37899385; PMCID: PMC10796483.

[13] Shinomiya K, Fujimura K, Kim Y, Kamei C. Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. Acta Med Okayama. 2005 Jun; 59(3):89-92. doi: 10.18926/AMO/31980. PMID: 16049561.

[14] Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. Com-plement Ther Med. 2017 Dec; 35:109-114. doi: 10.1016/j.ctim.2017.09.010. Epub 2017 Oct 13. PMID: 29154054.

[15] Kramer DJ, Johnson AA. Apigenin: a natural molecule at the intersection of sleep and aging. Front Nutr. 2024 Feb 27; 11:1359176. doi: 10.3389/fnut.2024.1359176. PMID: 38476603; PMCID: PMC10929570.

[16] Ngan A, Condutt R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality [J]. Phytother Res., 2011, 25(8):1153.

[17] Dimpfel W, Koch K, Weiss G. Early effect of NEURAPAS® balance on current source density (CSD) of human EEG [J]. BMC Psychiatry, 2011, doi:10.1186/1471-244x-11-123.

[18] Zou Jiangbing, Yuan Jin, Jiang Linlan. Preliminary Exploration of the Anxiolytic Effect and Mechanism of Purple Pitaya Leaf Extracts. In: Proceedings of the Guangdong Pharmaceutical Association 2016 Annual Conference [C]. Guangdong Pharmaceuti-cal Association: Guangdong Pharmaceutical Association, 2015:6.

[19] Chan YY, Chen YH, Yang SN, Lo WY, Lin JG. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Com-plement Alternat Med., 2015; 2015:710895. doi: 10.1155/2015/710895. Epub 2015 Aug 4. PMID: 26346534; PMCID: PMC4539464.

[20] Wang Ying, Sun Qingqing, Zhang Yanan, et al. Research Progress on the Mechanism of Suanzaoren Decoction in Treating In-somnia Disorders. World Journal of Sleep Medicine, 2023, 10(05):1199-1201.

[21] Haybar, H., Javid, A. Z., Haghighizadeh, M. H., Valizadeh, E., Mohaghegh, S. M., & Mohammadzadeh, A. (2018). The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clinical Nutrition ESPEN, 26, 47-52. https://doi.org/10.1016/j.clnesp.2018.04.015.

[22] Yin XJ, Lin GP, Wu XY, Huang R, Xu CJ, Yao MY. Effects of lavender essential oil inhalation aromatherapy on depression and sleep quality in stroke patients: A single-blind randomized controlled trial. Complement Ther Clin Pract. 2024 May; 55:101828. doi: 10.1016/j.ctcp.2024.101828. Epub 2024 Jan 14. PMID: 38241803.

[23] Zhou Xin, Song Ning, Lin Jing, et al. Study on the Sedative Effect and Mechanism of Lavender Essential Oil Aromatherapy Inha-lation in Sleep Aid. Journal of Central South Pharmacy, 2023, 21(09):2316-2321.

[24] Rose KM, Taylor AG, Bourguignon C. Effects of cranial electrical stimulation on sleep disturbances, depressive symptoms, and caregiving appraisal in spousal caregivers of persons with Alzheimer's disease. Appl Nurs Res., 2009 May; 22(2):119-25. doi: 10.1016/j.apnr.2007.06.001. PMID: 19427574; PMCID: PMC2713101.

[25] Dai Qianyi. Clinical Study on Transcranial Microcurrent Stimulation Combined with Acupuncture in the Treatment of Insomnia [D]. Beijing University of Chinese Medicine, 2016.

How to cite this paper

Analysis of Active Ingredients and Mechanisms of Action in Sleep Supplements: A Study Based on Market Conditions

How to cite this paper: Zhuotao Zeng, Huan Zeng, Junjiong Lu, Yuxi Huang, Xiaoyun Wen, Li Ding. (2024) Analysis of Active Ingredients and Mechanisms of Action in Sleep Supplements: A Study Based on Market Conditions. International Journal of Clinical and Experimental Medicine Research8(3), 512-517.

DOI: http://dx.doi.org/10.26855/ijcemr.2024.07.025