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Genital herpes, caused by the herpes simplex viruses (HSVs) is a globally sexually transmitted disease that has been more drastic in recent years. In this work, we have studied the epidemiological model applied to Herpes Simplex Virus Type 2 (HSV-2) infection in an optimal control perspective. The mathematical model that is developed in this work representing the disease dynamics is based on ordinary differential equations. Here we have employed the optimal control strategies to study the necessary mathematical analysis such as the existence and characterization of optimal control including some necessary conditions of the model. Our goal is to find a strategy using which we can prevent this disease by reducing HSV-2 infection. For this purpose, we have applied Pontryagin’s maximum principle and adopted vaccination as the control measure. We have examined the model both analytically and numerically, and the analytical findings have been illustrated using numerical simulations. After illustrating the graphs in different types of situations, we conclude that vaccination could be the most effective measure to reduce the number of infected individuals.
[1] Sethi, S. P. and G. L. Thompson. (2000). Optimal Control Theory: Applications to Management Science and Economics, Kluwer, Boston, 2nd edition.
[2] S. Lenhart, J. Workman. (2007). Optimal control applied to biological models. Taylor and Francis, Boca Raton.
[3] Looker KJ, Garnett GP, Schmid GP. (2008). An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ., vol. 86(10):805-812.
[4] C.N. Podder and A. B. Gumel. (2010). Qualitative dynamics of a vaccination model for HSV-2. IMA Journal of Applied Mathematics, vol. 75 (1): 75-107.
[5] W. H. Fleming and R. W. Rishel. (1975). Deterministic and Stochastic Optimal Control. Springer-Verlag.
[6] William E. Boyce and Richard C. DiPrima. (2009). Elementary Differential Equations and Boundary Value Problems. John Wiley and Sons, New York.
[7] Pontryagin, L. S., V. G. Boltyanskii, R. V. Gamkrelize, and E. F. Mishchenko. (1962). The Mathematical Theory of Optimal Processes, New York, Wiley.
[8] Michael, T.H. (2002). Scientific Computing: An introductory survey. Second edition, The McGraw-Hill, New York.
[9] H. M. Yang and A. R. R. Freitas. (2019). Biological view of vaccination described by mathematical modellings: from rubella to dengue vaccines. Mathematical Biosciences and Engineering, vol. 16(4):3195-3214.
[10] L. B, E. Z, and A. Z. (2022). Dynamical behaviors of an SIR epidemic model with discrete time. Fractal Fract., vol. 6(11):659.
[11] Bibi Fatima, Mehmet Yavu, Mati Ur Rahman, Fuad S Al-Duais. (2023). Modeling the epidemic trend of middle eastern respiratory syndrome coronavirus with optimal control. Mathematical Biosciences and Engineering, vol. 20(7):11847-11874.
[12] M. N. V, M. Z. E, A. O, et al. (2021). The impact of rubella vaccine introduction on rubella infection and congenital rubella syndrome: a systematic review of mathematical modelling studies. Vaccines, vol. 9 (2): 84.
[13] Corey L, Wald A. Genital Herpes. (1999). Sexually transmitted diseases. In: Holmes KK, Sparling PF, Mardh PA, et al, eds. New York, NY: McGraw-Hill, pp. 285-312.
[14] G. Zaman, Y. Kang, I. Jung. (2008). Stability analysis and optimal vaccination of an SIR epidemic model. BioSystems, vol. 93: 240-249.
[15] Gaff, E. Schaefer. (2009). Optimal control applied to vaccination and treatment strategies for various epidemiological models. Mathematical Biosciences and Engineering, vol. 6: 469-492.
[16] Kaminester L., Pariser R., Pariser D., Weiss J., Shavin J., Landsman L., Haines H., and Osborne D. (1999). A double-blind, pla-cebo-controlled study of topical tetracaine in the treatment of herpes labialis. Journal of the American Academy of Dermatology, vol. 41(6): 996-1001.
Optimal Control Strategies for Reducing Herpes Simplex Virus Type 2 (HSV-2) Infections
How to cite this paper: Samiha Islam Tanni, Chandra Nath Podder. (2024) Optimal Control Strategies for Reducing Herpes Simplex Virus Type 2 (HSV-2) Infections. Journal of Applied Mathematics and Computation, 8(3), 227-237.
DOI: https://dx.doi.org/10.26855/jamc.2024.09.005