IJCEMR
Research Progress on Changes in Circulating Levels of Growth Differentiation Factor 15
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Abstract
Growth differentiation factor-15 (GDF15) is a stress-responsive cytokine that has a significant impact on the health and lifespan of organisms. Although GDF15 was identified over 20 years ago, its functionality remains complex and has not been fully elucidated. GDF15 has been considered to regulate food intake and insulin sensitivity in rodents through the GDNF family receptor alpha-like (GFRAL) receptor, which increases during pregnancy and many disease states. Under normal physiological conditions, GDF15 is expressed at low concentrations in multiple tissues. In some pathological condi-tions, such as tissue damage and inflammation, GDF15 may be overexpressed, providing a protective effect. GDF15 has a certain value as a poten-tial biomarker in many diseases. Therefore, the research and application of GDF15 are expected to become an important direction for the diagnosis and treatment of related diseases. However, specific secretion regulation needs further research. This review particularly emphasizes its metabolic regulatory potential and discusses the roles of age, gender, lifestyle, and metabolic parameters in regulating GDF15 circulation levels.
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How to cite this paper
Research Progress on Changes in Circulating Levels of Growth Differentiation Factor 15
How to cite this paper: Zilu Ren, Jianfeng Liu. (2025) Research Progress on Changes in Circulating Levels of Growth Differentiation Factor 15. International Journal of Clinical and Experimental Medicine Research, 9(1), 24-28.
DOI: http://dx.doi.org/10.26855/ijcemr.2025.01.005
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