Abstract

Objective: To observe the clinical analysis of 28 cases of HELLP syndrome. Methods: A retrospective analysis was carried out on 28 patients with HELLP syndrome admitted to our hospital from January 2015 to January 2025. Based on the classification, they were divided into a complete HELLP group and a partial HELLP group; based on the patients’ prognosis, they were divided into a good prognosis group and a poor prognosis group. The general and laboratory indicators were clarified for different classifications, and the factors affecting neonatal prognosis in the good prognosis group and poor prognosis group were analyzed. Results: Regarding the general and laboratory indicators in different classifications, there was no statistically significant difference (P > 0.05) between the complete HELLP group and the partial HELLP group in terms of age, gestational weeks, platelet (PLT) count, and total bilirubin (TBIL) levels. The ALT count in the complete group and the negative rate of peripheral smear were lower than those in the partial group, whereas the LDH count was higher than that in the partial group; the differences were statistically significant (P < 0.05). In the comparison of factors affecting neonatal prognosis between the good prognosis group and the poor prognosis group, the age of the good prognosis group was younger than that of the poor prognosis group, while gestational weeks and neonatal birth weight were higher, and the neonatal asphyxia rate was lower; these differences were statistically significant (P < 0.05). There was no statistically significant difference in classification between the two groups (P > 0.05). Conclusion: HELLP syndrome is characterized by severe disease progression and rapid deterioration. For such patients, timely and accurate diagnosis, rapid implementation of effective treatment, and timely termination of pregnancy when necessary are key measures to significantly reduce maternal and neona-tal mortality and improve prognosis.