IJCEMR

Article http://dx.doi.org/10.26855/ijcemr.2026.03.020

Surgical Treatment of Invasive IgG4-related Sclerosing Esophagitis Inflammatory Pseudotumor: A Case Report and Literature Review

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Weixin Liu, Xuefeng Zhang, Jiacong Wei, Ling Qi, Yong Li^*

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

*Corresponding author: Yong Li

Beijing-Tianjin-Hebei Basic Research Project of Tianjin Science and Technology Bureau (Grant Numbers: 22JCZXJC00040); the National Natural Science Foundation of China (Grant No. 22478441).

Published: March 31,2026

Abstract

IgG4-related sclerosing disease (IgG4-RSD) is an uncommon autoimmune entity, manifesting as tumefactive lesions and fibrosis in a spectrum of organs, including the pancreas, biliary tract, and salivary glands. Involvement of the esophagus is exceedingly rare. We present herein a case of an invasive IgG4-related sclerosing esophagitis pseudotumor, confirmed through surgical intervention and pathological assessment. A 26-year-old female exhibited symptoms of dysphagia and significant weight loss over a six-month period. Esophagoscopy disclosed a mass-like lesion localized to the upper esophagus. Preoperative biopsies, performed on two occasions, identified squamous epithelial cells, pointing towards a mesenchymal tumor in the differential diagnosis. Following a comprehensive multidisciplinary consultation, surgical resection was elected owing to the lesion’s extensive nature and the patient’s pronounced symptoms. Histopathological examination substantiated the presence of an esophageal tumor with the hallmarks of invasive IgG4-related sclerosing esophagitis. Postoperative recovery was uneventful, and the patient has remained asymptomatic throughout the follow-up period. This case illustrates the necessity of including IgG4-related disease in the differential diagnosis of esophageal tumors and accentuates the significance of surgical management in symptomatic and invasive instances of IgG4-related sclerosing esophagitis pseudotumors.

Keywords

IgG4-related disease; sclerosing esophagitis pseudotumor; surgical treatment; case report; literature review

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How to cite this paper

Surgical Treatment of Invasive IgG4-related Sclerosing Esophagitis Inflammatory Pseudotumor: A Case Report and Literature Review

How to cite this paper: Weixin Liu, Xuefeng Zhang, Jiacong Wei, Ling Qi, Yong Li. (2026) Surgical Treatment of Invasive IgG4-related Sclerosing Esophagitis Inflammatory Pseudotumor: A Case Report and Literature Review. International Journal of Clinical and Experimental Medicine Research, 10(2), 165-169.

DOI: http://dx.doi.org/10.26855/ijcemr.2026.03.020