IJCEMR
Comparative Evaluation of the Therapeutic Effects of Vitamin C Combined with Watermelon Frost and Kangfuxin Liquid on Oral Ulcers in Mice
TOTAL VIEWS: 495
Abstract
Objective: To investigate the therapeutic effects of Vitamin C combined with Watermelon Frost and Kangfuxin Liquid, respectively, on oral ulcers in mice. Methods: Forty SPF Kunming mice were randomly divided into 5 groups (n=8): control group, Watermelon Frost group, Kangfuxin Liquid group, Vitamin C + Watermelon Frost group, and Vitamin C + Kangfuxin Liquid group. The oral ulcer model was established by chemical cauterization. After modeling, each group received corresponding drug intervention: the control group was given normal saline, single-drug groups were administered corresponding drugs alone, and combined-drug groups were additionally given 100 mg/kg Vitamin C solution on the basis of single drugs, twice daily for 7 consecutive days. The healing time, recovery rate, ulcer area reduction rate, and body weight changes of oral ulcers in mice were observed and recorded. Statistical analysis was performed using SPSS 26.0 software. Results: The therapeutic effects of the combined-drug groups were significantly better than those of the single-drug groups and the control group (P<0.05). Among them, the Vitamin C + Kangfuxin Liquid group showed the optimal efficacy, with a 3-day and 4-day recovery rate both reaching 1.0000±0.0000, a healing time of 3.50±0.85 d, and an ulcer area reduction rate of 95.20±6.55%. The weight loss in all medication groups was less than that in the control group (P<0.05). Conclusion: Vitamin C combined with Watermelon Frost or Kangfuxin Liquid can significantly promote the healing of oral ulcers in mice, shorten the healing time, and improve the recovery rate, and Vitamin C combined with Kangfuxin Liquid presents superior efficacy, which is worthy of further clini-cal promotion.
Keywords
Vitamin C; Watermelon Frost; Kangfuxin Liquid; oral ulcer; mouse model
References
[1] Of JEH. Retracted: Effects of four types of watermelon frost combination medications for the treatment of oral ulcers: a network meta-analysis. J Healthc Eng. 2023;2023:9896325.
DOI: 10.1155/2023/9896325.
[2] Zhenhua L, Huiqin D. Effects of four types of watermelon frost combination medications for the treatment of oral ulcers: a network meta-analysis. J Healthc Eng. 2022;2022:2712403. DOI: 10.1155/2022/2712403.
[3] St. R, Takdir T, Saldy Y. The effect of Buerger Allen exercise and the provision of oral vitamin C toward the improvement of peripheral tissue perfusion and healing of diabetic foot ulcers. Enferm Clin. 2021;31(S5):S709-S712. DOI: 10.1016/j.enfcli.2021.07.022.
[4] Shen L, Chen X, Zhang T. Assessment of the anti-inflammatory efficacy and symptom resolution time of Kangfuxin liquid combined with metronidazole in recurrent oral ulcers. J Inflamm Res. 2025;18:11925-11934. DOI: 10.2147/JIR.S534657.
[5] Leong W, Xu K, Ip Y. Comparative study on the efficacy of Kangfuxin liquid combined with oral ulcer powder of recurrent oral ulcers: a meta-analysis. Acad J Med Health Sci. 2024;5(5). DOI: 10.25236/AJMHS.2024.050501.
[6] Li D, Yu Y, Fan R, et al. An EGCG-enhanced pH/ROS dual-responsive hyaluronic acid hydrogel loaded with ginseng-derived exosomes for diabetic oral ulcers treatment. Int J Biol Macromol. 2025;339(Pt 2):149497. DOI: 10.1016/j.ijbiomac.2025.149497.
[7] Nasim M, Haider F, Khan M, et al. Development and evaluation of a spray formulation combining triamcinolone acetonide and lidocaine for enhanced healing of mouth ulcers. J Drug Deliv Sci Technol. 2026;115(Pt 2):107728. DOI: 10.1016/j.jddst.2025.107728.
[8] Zhang X, Li X, Huoshen W, et al. Identification of drugs associated with oral ulcers based on pharmacovigilance. Int Dent J. 2025;75(6):103957. DOI: 10.1016/j.identj.2025.103957.
How to cite this paper
Comparative Evaluation of the Therapeutic Effects of Vitamin C Combined with Watermelon Frost and Kangfuxin Liquid on Oral Ulcers in Mice
How to cite this paper: Kaixin Chen, Hongyuan Shen, Zhijie Sun. (2026) Comparative Evaluation of the Therapeutic Effects of Vitamin C Combined with Watermelon Frost and Kangfuxin Liquid on Oral Ulcers in Mice. International Journal of Clinical and Experimental Medicine Research, 10(3), 207-210.
DOI: http://dx.doi.org/10.26855/ijcemr.2026.05.007
More Articles
- Application of Visualized Precise Electrophysiological Therapy Combined with Electrothermal Acupuncture in Patients with Spinal Cord Injury and Neurogenic Bowel Dysfunction
- Risk Factors and Prevention Strategies of Perioperative Myocardial Injury in Elderly Patients with Complex Coronary Artery Lesions Undergoing Interventional Therapy
- Efficacy and Safety Analysis of Sintilimab Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer
- Impact of Preformed Crown Restoration Combined with Non-invasive Filling Technique on Young Children with Severe Dental Caries
- Evaluation of the Efficacy of Camrelizumab Combined with Chemotherapy in the Treatment of Lung Cancer
- Correlation Analysis of Clinical Phenotypes, Inflammatory Molecular Markers, and Susceptibility Gene Polymorphisms in Acne Patients in Urumqi and Construction of Treatment Regimens