IJCEMR

Article http://dx.doi.org/10.26855/ijcemr.2026.07.008

Application of Immunotherapy Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer

TOTAL VIEWS: 367

Xia Kang^1,2,3, Lin Yu^2,*

¹School of Clinical Medicine, Chengdu Medical College, Chengdu 610500, Sichuan, China.

²Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China.

³Key Laboratory of Geriatric Respiratory Diseases of Sichuan Higher Education Institutes, Chengdu 610500, Sichuan, China.

*Corresponding author: Lin Yu

Published: July 2,2026

Abstract

Objective: To explore the application value of immunotherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: From December 2024 to November 2025, 82 patients with advanced NSCLC were selected. All subjects had an expected survival duration of ≥3 months and were divided into two groups according to a random number table method. Both groups received chemotherapy treatment clinically, while the observation group patients were required to undergo combined immunotherapy. The application effects were compared. Results: The ORR and DCR values in the observation group were 58.54% and 87.80%, respectively, while those in the reference group were 34.15% and 68.29%, respectively. The differences between the two groups were significant (P<0.05). The improvement in immune function indicators in the observation group was superior to that in the reference group (P<0.05). The actual proportions of adverse events in the two groups were 29.27% and 31.71%, respectively, with no significant difference in data comparison (P>0.05). Conclusion: Based on the actual situation of patients with advanced NSCLC, the implementation of immunotherapy combined with chemotherapy can help improve short-term clinical efficacy, enhance patients’ immune function, and does not significantly increase toxic side effects. It is worthy of clinical promotion and application.

Keywords

Immunotherapy; chemotherapy; advanced stage; non-small cell lung cancer; clinical efficacy

References

[1] Wang Q. Clinical efficacy of immunotherapy combined with bevacizumab-based chemotherapy in patients with advanced driver genenegative non-squamous non-small cell lung cancer. Smart Health. 2025;11(33):31-34.

doi:10.19335/j.cnki.2096-1219.2025.33.009.

[2] Zhang WL, Li HY, Chen FM. Impact of immune checkpoint inhibitors combined with chemotherapy on lung function and prognosis in patients with advanced non-small cell lung cancer. Jilin Med J. 2025;46(10):2495-2498.

[3] Li MW, Xue JZ, Pan N. The impact of immune checkpoint inhibitors combined with chemotherapy on advanced non-small cell lung cancer. J Baotou Med Coll. 2025;41(8):66-70.
doi:10.16833/j.cnki.jbmc.2025.08.012.

[4] Li ZH, Wang X, Wang YL, Sun Y, Liu J, Zhao Q, et al. Analysis of the efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in patients with stage IB-IIIB non-small cell lung cancer. Chin J Lung Cancer. 2025;28(6):415-426.

[5] Huang WJ. The impact of durvalumab combined with chemotherapy on immune function and tumor markers in patients with ad-vanced non-small cell lung cancer. Chin Foreign Med Res. 2025;4(17):13-15.

[6] Chen QH. Application of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer. J Pract Integr Tradit Chin West Med Clin Pract. 2024;24(18):17-19,77.
doi:10.13638/j.issn.1671-4040.2024.18.005.

[7] Wu CZ, Zheng H, Sheng SY, Li X, Zhang Y, Wang L, et al. Preliminary efficacy observation of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer. J Cap Med Univ. 2024;45(4):642-648.

[8] Li HY, Yin HL. The effect of immunotherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Mingyi. 2024;(1):6-8.
doi:10.20255/j.cnki.issn1674-9561.2024.01.003.

How to cite this paper

Application of Immunotherapy Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer

How to cite this paper: Xia Kang, Lin Yu. (2026) Application of Immunotherapy Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer. International Journal of Clinical and Experimental Medicine Research, 10(4), 299-302.

DOI: http://dx.doi.org/10.26855/ijcemr.2026.07.008