IJCEMR

Article http://dx.doi.org/10.26855/ijcemr.2022.04.005

Cystic Echincoccoosis: A Comprehensive Review on Life Cycle, Epidemiology, Pathogenesis, Clinical Spectrum, Diagnosis, Public Health and Economic Implications, Treatment, and Control

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Mahendra Pal1,*, Habtamu Hibistu Alemu2, Lencho Megersa Marami3, Derartu Roba Garedo2, Ebisa Bane Bodena2

1Narayan Consultancy on Veterinary Public Health and Microbiology, Anand, India. 

2Department of Veterinary Science, Guder Mamo Mezemer Campus, School of Veterinary Medicine, Ambo University, Ambo, Oromia, Ethiopia. 

3Department of Veterinary Laboratory Technology, Guder Mamo Mezemer Campus, School of Veterinary Medicine, Ambo University, Ambo, Oromia, Ethiopia.

*Corresponding author: Mahendra Pal

Published: March 22,2022

Abstract

The larval (metacestode) stage of cestodes belonging to the genus Echinococcus, family Taeniidae, causes echinococcosis, which is one of the most serious tropical helminthic infections of livestock with financial and public health implications in both developed and developing countries. The larval stage of Echinococcus granulosus causes cystic echinococcosis (CE), a serious zoonosis.  Cystic echinococcosis causes significant economic loss in farm animals due to the condemnation of edible organs, decreased meat and milk output, lower hide and fleece value, and decreased reproduction. In humans, economic loss refers to monetary losses incurred as a result of diagnosis, hospitalization, surgical intervention, or percutaneous therapies. Treatments, post-treatment care, and travel for patients and family members, as well as indirect costs, such as mortality and suffering. With the exception of Antarctica and nations where echinococcosis has been eradicated by extensive control efforts, such as Iceland, New Zealand, Tasmania, and the Falkland Islands, it is associated with substantial economic losses and public health significance globally. Carnivores are well-known for being terrific hosts. The infection occurs when humans consume parasite eggs found in the contaminated food, drink, or soil, or when they come into direct contact with animal hosts. Specific control measures include stray-dog control, registration of all owned dogs, spaying of bitches, and praziquantel medication of all (or most) dogs at predetermined intervals (such as every 6 or 8 weeks), strict meat inspection, proper disposal of affected viscera of food animals, and health education.

References

[1] Ali, R., Khan, S., Khan, M., Adnan, M., Ali, I., Khan, T. A., Haleem, S., Rooman, M., Norin, S., and Khan, S. N. (2020).  A systematic review of medicinal plants used against Echinococcus granulosus.  PLOS ONE,15(10), e0240456.  https://doi.org/10.1371/journal.pone.0240456. 

[2] Jones, O., Kebede, N., Kassa, T., Tilahun, G. T., and Macias, C. (2012).  Occurrence of bovine hydatidosis and evaluation of its risk to humans in traditional communities of Southern Region of Ethiopia.  Ethiopian Journal of Health Development, 26, 43-48. 

[3] Ahmed, M. E., Abdelrahim, M. I., and Ahmed, F. M. (2011).  Hydatid disease, a morbid drop needs awareness.  Sudan Medical Journal, 47(1), 4-8. 

[4] Tilahun, A. and Terefe, Y. (2013).  Hydatidosis: prevalence, cyst distribution and economic significance in cattle slaughtered at Arbaminch municipality abattoir, Southern Ethiopia.  Global Veterinaria, 11(3), 329-334. 

[5] Deplazes, P., Rinaldi, L., Alvarez Rojas, C. A., Torgerson, P. R., Harandi, M. F., Romig, T., Antolova, D., Schurer, J. M., Lahmar, S., Cringoli, G., Magambo, J., Thompson, R. C., and Jenkins, E. J. (2017).  Global distribution of alveolar and cystic echinococcosis.  Advances in Parasitology, 95, 315-493.  https://doi.org/10.1016/bs.apar.2016.11.001. 

[6] Hüttner, M., Nakao, M., Wassermann, T., Siefert, L., Boomker, J. D., Dinkel, A., Sako, Y., Mackenstedt, U., Romig, T., and Ito, A. (2008).  Genetic characterization and phylogenetic position of Echinococcus felidis (Cestoda: Taeniidae) from the African lion.  International Journal for Parasitology, 38 (7), 861-868.  https://doi.org/10.1016/j.ijpara.2007.10.013. 

[7] Xiao, N., Qiu, J., Nakao, M., Li, T., Yang, W., Chen, X., Schantz, P. M., Craig, P. S., and Ito, A. (2005).  Echinococcus shiqui-cus n. sp., a taeniid cestode from Tibetan fox and plateau pika in China.  The International Journal for Parasitology, 35(6), 693-701.  https://doi.org/10.1016/j.ijpara.2005.01.003. 

[8] Jackson, S. M., Groves, C., Fleming, P. J., Aplin, K. P., Eldridge, M. D., Gonzalez, A., and Helgen, K. M. (2017).  The wayward dog: is the Australian native dog or dingo a distinct species?  Zootexa, 4317(2): 201-224.  https://doi.org/10.11646. 

[9] Carmena, D. and Cardona, G. A. (2013).  Canine echinococcosis: global epidemiology and genotypic diversity.  Acta Tropica, 128(3), 441-460.  https://doi.org/10.1016/j.actatropica.2013.08.002. 

[10] Chhabra, M. B. and Singla, L. D. (2009).  Food-borne parasitic zoonoses in India: Review of recent reports of human infections.  Journal of Veterinary parasitology, 23, 103-110. 

[11] Rausch, R. (1995).  Life cycle patterns and geographic distribution of Echinococcus species.  Echinococcus and hydatid disease. 

[12] Neumayr, A., Tamarozzi, F., Goblirsch, S., Blum, J., and Brunetti, E. (2013).  Spinal cystic echinococcosis—a systematic analysis and review of the literature: part 1.  Epidemiology and anatomy.  PLOS Neglected Tropical Diseases, 7(9), e2450.  https://doi.org/10.1371/journal.pntd.0002450. 

[13] Aboelhadid, S. M., El-Dakhly, K. M., Yanai, T., Fukushi, H., and Hassanin, K. M. (2013).  Molecular characterization of Echinococcus granulosus in Egyptian donkeys.  Veterinary Parasitology, 193(1-3), 292-296.  https://doi.org/10.1016/j.vetpar.2012.  11.019 

[14] Agudelo Higuita, N. I., Brunetti, E., and McCloskey, C. (2016).  Cystic Echinococcosis.  Journal of Clinical Microbiology, 54(3), 518-523.  https://doi.org/10.1128/jcm.02420-15. 

[15] Radfar, M. H. and Iranyar, N. (2004).  Biochemical profiles of hydatid cyst fluids of Echinococcus granulosus of human and animal origin in Iran.  Journal of Veterinary Science, 4(6), 435-442. 

[16] Craig, P. S., McManus, D. P., Lightowlers, M. W., Chabalgoity, J. A., Garcia, H. H., Gavidia, C. M., Gilman, R. H., Gonzalez, A. E., Lorca, M., Naquira, C., Nieto, A., and Schantz, P. M. (2007).  Prevention and control of cystic echinococcosis.  Lancet Infectious Diseases, 7(6), 385-394.  https://doi.org/10.1016/s1473-3099(07)70134-2. 

[17] Magambo, J., Njoroge, E., and Zeyhle, E. (2006).  Epidemiology and control of echinococcosis in sub-Saharan Africa.  Parasitology International, 55 Suppl, S193-195.  https://doi.org/10.1016/j.parint.2005.11.029. 

[18] Torgerson, P. R., Karaeva, R. R., Corkeri, N., Abdyjaparov, T. A., Kuttubaev, O. T., and Shaikenov, B. S. (2003).  Human cystic echinococcosis in Kyrgystan: an epidemiological study.  Acta Tropica, 85(1), 51-61.  https://doi.org/10.1016/s0001-706x(02) 00257-7. 

[19] Rahman, W., Elmajdoub, L., Noor, S., and Wajidi, M. (2015).  Present status on the taxonomy and morphology of Echinococcus granulosus: A review.  Ustin Journal of Veterinary Science & Animal Husbandry, 2(2). 

[20] WHO/OIE.  (2002).  Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern. 

[21] Thompson, R. C. A. (2008).  The taxonomy, phylogeny and transmission of Echinococcus.  Experimental Parasitology, 119(4), 439-446.  https://doi.org/10.1016/j.exppara.2008.04.016

[22] Eckert, J. and Deplazes, P. (2004). Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clinical Microbiology Reviews, 17(1), 107-135. https://doi.org/10.1128/cmr.17.1.107-135.2004.

[23] Mandal, S. and Mandal, M. D. (2012). Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine, 5(4), 253-260. https://doi.org/10.1016/s1995-7645(12)60035-2.

[24] Daryani, A., Alaei, R., Arab, R., Sharif, M., Dehghan, M. H., and Ziaei, H. (2007). The prevalence, intensity and viability of hydatid cysts in slaughtered animals in the Ardabil province of Northwest Iran. Journal of Helminthology, 81(1), 13-17. https://doi.org/10.1017/s0022149x0720731x.

[25] Schantz, P. M. (2006). Progress in diagnosis, treatment and elimination of echinococcosis and cysticercosis. Parasitology In-ternational, 55 Suppl, S7-s13. https://doi.org/10.1016/j.parint.2005.11.050.

[26] Jemalo, A., Haile, G., and Furgasa, W. (2018). Major causes of organ condemnation and Their economic loss in beef cattle slaughtered at Assella Municipal Abattoir. Journal of Veterinary Science and Animal Husbandry, 6(2), 208. 

[27] CDC. (2019). Echinococcosis. Retrieved December 23 from https://www.cdc.gov/dpdx/echinococcosis/.

[28] Coughlin, S. S., Beauchamp, T. L., and Weed, D. L. (2009). Ethics and epidemiology. Oxford University Press. 

[29] Abegaz, S. and Mohammode, A. (2018). Crossectional study on the prevalence and economic significance of hydatidosis in slaughtered ruminants at Debre Zeit Elfora Export Abattoir Oromia Region Eastern Showa Zone, Ethiopia. Biomedical Journal of Scientific & Technical Research, 3(3), 3273-3282. 

[30] Toulah, F. H., El Shafei, A. A., & Alsolami, M. N. (2012). Prevalence of hydatidosis among slaughtered animals in Jeddah, Kingdom of Saudi Arabia. Journal of the Egyptian Society of Parasitology, 42(3), 563-572. https://doi.org/10.12816/0006341.

[31] Eckert, J., Schantz, P., Gasser, R., Torgerson, P., Bessonov, A., Movsessian, S., Thakur, A., Grimm, F., and Nikogossian, M. (2001). Geographic distribution and prevalence. WHO/OIE manual on echinococcosis in humans and animals: A public health problem of global concern, 100-142. 

[32] Ito, A., Urbani, C., Jiamin, Q., Vuitton, D. A., Dongchuan, Q., Heath, D. D., Craig, P. S., Zheng, F., and Schantz, P. M. (2003). Control of echinococcosis and cysticercosis: a public health challenge to international cooperation in China. Acta Tropica, 86(1), 3-17. https://doi.org/10.1016/s0001-706x(02)00269-3.

[33] Budke, C. M., Deplazes, P., and Torgerson, P. R. (2006). Global socioeconomic impact of cystic echinococcosis. Emerging Infectious Diseases, 12(2), 296-303. https://doi.org/10.3201/eid1202.050499.

[34] Nasr, W. and Pal, M. (2016). Prevalence, cyst viability, fertility and economic significance of bovine hydatidosis in an abattoir at Kombolcha, Ethiopia. Haryana Veterinarian, 55, 17-22. 

[35] WHO. (2016). Echinococcosis: WHO Fact Sheet. 

[36] McManus, D. P. (2010). Echinococcosis with particular reference to Southeast Asia. Advances in Parasitology, 72, 267-303. https://doi.org/10.1016/s0065-308x(10)72010-8.

[37] Azlaf, R. and Dakkak, A. (2006). Epidemiological study of the cystic echinococcosis in Morocco. Veterinary Parasitology, 137(1-2), 83-93. https://doi.org/10.1016/j.vetpar.2006.01.003.

[38] Ibrahim, S. E. A. (2014). Pathological, histochemical and immunohistochemical studies of lungs and livers of cattle and sheep infected with hydatid disease. 

[39] Akeberegn, D., Alemneh, T., and Kassa, T. (2017). The prevalence of bovine hydatidosis among slaughtered cattle at Debre Berhan Municipal Abattoir, North Shewa Zone, Ethiopia. Journal of Veterinary Science and Medicine, 5(1), 5. 

[40] Kavukcu, S., Kilic, D., Tokat, A. O., Kutlay, H., Cangir, A. K., Enon, S., Okten, I., Ozdemir, N., Gungor, A., Akal, M., and Akay, H. (2006). Parenchyma-preserving surgery in the management of pulmonary hydatid cysts. Journal of Investigative Surgery, 19(1), 61-68. https://doi.org/10.1080/08941930500444586.

[41] Hemachander, S. S., Prasad, C. R., and Jessica, M. (2008). Morbidity pattern of hydatid disease (cystic echinococcosis) and lack of its knowledge in patients attending Mamata General Hospital, Khammam, Andhra Pradesh. The Indian Journal of Pathology and Microbiology, 51(1), 143-145. https://doi.org/10.4103/0377-4929.40429.

[42] Salem, C. O., Schneegans, F., Chollet, J., and Jemli, M. E. (2011). Epidemiological studies on echinococcosis and characterization of human and livestock hydatid cysts in mauritania. Iranian Journal of Parasitology, 6(1), 49-57. 

[43] Taylor, M. A., Coop, R. L., and Wall, R. L. (2003). Veterinary Parasitology (3rd Edition ed.). Blackwell. 

[44] McManus, D. P., Gray, D. J., Zhang, W., and Yang, Y. (2012). Diagnosis, treatment, and management of echinococcosis. British Medical Journal, 344, e3866. https://doi.org/10.1136/bmj.e3866.

[45] Wani, N. A., Kousar, T. L., Gojwari, T., Robbani, I., Singh, M., Ramzan, A., Khan, Q., Kirmani, A., and Wani, A. (2011). Computed tomography findings in cerebral hydatid disease. Turkish Neurosurgery, 21(3), 347-351. https://doi.org/10.5137/1019-5149.Jtn.3922-10.0.

[46] Limaiem, F., Bellil, S., Bellil, K., Chelly, I., Mekni, A., Khaldi, M., Haouet, S., Zitouna, M., and Kchir, N. (2010). Primary hydatidosis of the central nervous system: a retrospective study of 39 Tunisian cases. Clinical neurology and neurosurgery, 112(1), 23-28. 

[47] Tsaroucha, A. K., Polychronidis, A. C., Lyrantzopoulos, N., Pitiakoudis, M. S., Karayiannakis, A. J., Manolas, K. J., and Simopoulos, C. E. (2005). Hydatid disease of the abdomen and other locations. World Journal of Surgery, 29(9), 1161-1165. 

[48] Urquhart, G. M., Armour, J., Dunca, J. L., Dunn, A. M., and Jennings, F. W. (1996). Veterinary Parasitology (2nd Edition ed.). Blackwell Science Ltd. 

[49] FAO. (1982). Guideline for surveillance, prevention and control of echinococus/hydatidosis. Food and Agriculture organization of the United Nation, Rome Italy. 20-21. 

[50] Bernthaler, P., Epping, K., Schmitz, G., Deplazes, P., and Brehm, K. (2009). Molecular characterization of EmABP, an apolipoprotein A-I binding protein secreted by the Echinococcus multilocularis metacestode. Infection and immunity, 77(12), 5564-5571. https://doi.org/10.1128/IAI.00653-09.

[51] CFSPH. (2011). Echinococcosis. Center for Food Security and Public Health, USA.

[52] Torgerson, P. R. and Macpherson, C. N. (2011). The socioeconomic burden of parasitic zoonoses: global trends. Veterinary parasitology, 182(1), 79-95. 

[53] Pakala, T., Molina, M., and Wu, G. Y. (2016). Hepatic echinococcal cysts: a review. Journal of Clinical and Translational Hepatology, 4(1), 39. 

[54] Fikire, Z., Tolosa, T., Nigussie, Z., and Kebede, N. (2012). Prevalence and characterization of hydatidosis in animals slaughtered at Addis Ababa abattoir, Ethiopia. Journal of Parasitology and Vector Biology, 4(1), 1-6. 

[55] Fromsa, A. and Jobre, Y. (2012). Estimated annual economic loss from organ condemnation, decreased carcass weight and milk yield due to bovine hydatidosis (Echinococcus granulosus, Batsch, 1786) in Ethiopia. Ethiopian Veterinary Journal, 16(2), 1-14. 

[56] Ochi, E. B., Akol, D. A., and Lukaw, Y. S. (2016). A review on epidemiology of hydatidosis in livestock and humans in South Sudan. International Journal of Research Studies in Biosciences, 4(10), 4-10. 

[57] WHO. (2011). Report of the World Health Organization Informal Working Group on Cystic and Alveolar Echinococcosis Surveillance, Prevention and Control. Geneva, Switzerland.

[58] Macpherson, C., Bartholomot, B., and Frider, B. (2003). Application of ultrasound in diagnosis, treatment, epidemiology, public health and control of Echinococcus granulosus and E. multilocularis. Parasitology, 127(S1), S21-S35. 

[59] Fato, M. A. (2017). Study on prevalence of small ruminants hydatidosis and its economic Importance at Gindhir Municipal Abboittar. European Journal of Biological Sciences, 9(1), 27-34. 

[60] Moro, P. and Schantz, P. M. (2009). Echinococcosis: a review. International Journal of Infectious Diseases, 13(2), 125-133. 

[61] Torgerson, P. and Budke, C. (2003). Echinococcosis—an international public health challenge. Research in veterinary science, 74(3), 191-202.

[62] Nejad, M. R., Mojarad, E. N., Norouzina, M., and Harandi, M. F. (2010). Echinococcosis: based on molecular studies in Iran. Gastroenterology and Hepatology from Bed to Bench, 3(4). 

[63] Sinan, T., Sheikh, M., Chisti, F. A., Al Saeed, O., Sheikh, Z., Hira, P. R., and Behbehani, A. (2002). Diagnosis of abdominal hydatid cyst disease: the role of ultrasound and ultrasound-guided fine needle aspiration cytology. Medical Principles and Practice, 11(4), 190-195. https://doi.org/10.1159/000065809.

[64] Pal, M. (2007). Zoonoses. Second Edition. Satyam Publishers, Jaipur, India.

[65] Pal, M. and Dutta, J. B. (2013). Echinococcosis: An emerging and re-emerging cyclozoonosis of global significance. International Journal of Livestock Healt, 3(3): 5-13.

How to cite this paper

Cystic Echincoccoosis: A Comprehensive Review on Life Cycle, Epidemiology, Pathogenesis, Clinical Spectrum, Diagnosis, Public Health and Economic Implications, Treatment, and Control

How to cite this paper: Mahendra Pal, Habtamu Hibistu Alemu, Lencho Megersa Marami, Derartu Roba Garedo, Ebisa Bane Bodena. (2022) Cystic Echincoccoosis: A Comprehensive Review on Life Cycle, Epidemiology, Pathogenesis, Clinical Spectrum, Diagnosis, Public Health and Economic Implications, Treatment, and Control. International Journal of Clinical and Experimental Medicine Research6(2), 131-141.

DOI: http://dx.doi.org/10.26855/ijcemr.2022.04.005